Methylene Blue: Worth it? We Cover Benefits, Uses, Dosage & Side Effects.

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What is Methylene Blue?

You probably heard about Methylene blue (MB) and its benefits on performance and endurance. You also may have heard in its ability to treat various health conditions.

Supplement freaks and biohackers have been touting the benefits of MB on social media for years now. In this article, we’ll cover everything you need to know about Methylene blue, its usage, dosage, benefits and side effects.

What is Methylene Blue And What Is It Used For?

is a synthetic compound originally used as a dye. Over time, it has found its way into medicine due to its therapeutic properties. Developed in the 1800s, it’s known today for being versatile in healthcare.

Fitness Benefits:

Methylene blue has recently sparked interest in the fitness community for its potential health benefits, although more research is needed to confirm these effects. One of the most intriguing possibilities is its role in enhancing mitochondrial function. Methylene blue is believed to improve the efficiency of mitochondria, the energy powerhouses of cells, enabling them to produce more ATP. This increase in cellular energy could potentially lead to heightened endurance and reduced fatigue during workouts, allowing athletes to train longer and harder.

Medical Treatments:

There is a lot of scientific literature on MB’s use as a treatment for various condisiont, such as:

  • Methemoglobinemia: It treats this condition where blood can’t release oxygen properly.
  • Malaria: Historically used as an anti-malaria medication.
  • Cyanide Poisoning: Acts as an antidote.
  • Alzheimer’s Disease: Being studied for possible brain health benefits.
  • Urinary Tract Infections (UTIs): Sometimes used to disinfect the urinary tract.
  • Sepsis: Early research suggests it may help in sepsis treatment.

Lab Research:

  • Microscope Staining: Stains cell structures to make them easier to see under a microscope.
  • Eosin Methylene Blue (EMB) Agar: Used in microbiology to distinguish different bacteria.

Aquarium Use:

  • Fish Treatment: Treats fish for fungal and parasitic infections.

    Methylene Blue Benefits

    Brain Health: Could help improve memory and slow cognitive decline.

    Cell Energy Boost: Supports mitochondrial function to give your metabolism a lift.

    Antioxidant Properties: Reduces oxidative stress, which may slow aging and improve skin health.

    Mental Clarity: Some people use it as a nootropic for better focus and mood.

    Anti-Microbial: Acts as a urinary antiseptic to prevent UTIs.

      How to Take Methylene Blue Orally

      IMPORTANT: the numbers below may not be accurate, as each specific supplement is different. Please follow the dosage instructions of the specific supplement you are buying.

      Methylene blue comes in capsules, tablets, and powder form. Here’s how to take it orally:


      • A typical dose ranges from 0.1 mg to 2 mg per kilogram of body weight.
      • For brain health, it’s often between 60 mcg and 100 mcg per kilogram.

      How to Take It:

      • Mix the powder or liquid in a glass of water or juice to mask its bitter taste.
      • Capsules and tablets can be swallowed with water.
      • IMPORTANT: always read the instructions of the specific MB supplement you purchased and follow their recommended dosage. Also, speak to your doctor or health practitionner before starting to consume MB.

        Methylene Blue Dosage

        Medical Dosage:

        • For methemoglobinemia, doctors often administer 1-2 mg/kg via IV.
        • For brain enhancement, talk to your doctor or healthcare practitionner for accurate dosing.

        Fish Treatment:

        • Add 1 teaspoon (about 5 ml) per 10 gallons of water.

          Methylene Blue Side Effects

          Common Side Effects:

          • Blue or green urine
          • Diarrhea
          • Stomach cramps
          • Nausea or vomiting

          Long-term Side Effects:

          Rarely, high doses over time may cause serotonin syndrome, especially if taken with certain antidepressants.


          Safe at recommended doses, but high doses can cause confusion and agitation.

          Drug Interactions:

          Can interact with certain medications like SSRIs and MAO inhibitors, increasing the risk of serotonin syndrome.

            Methylene Blue and Red Light Therapy

            A growing trend is combining methylene blue with red light therapy to improve brain health, boost mitochondrial function, and enhance skin health. Both treatments may work together to support energy production and reduce oxidative stress.

            Is Methylene Blue Safe?

            Methylene blue is generally safe if taken in the right dose. Make sure to talk to your healthcare provider before starting it, especially if you’re on other medications or have pre-existing conditions.

            Where to Find Methylene Blue Near Me

            You can buy methylene blue at pharmacies (with a prescription), online, or at supplement stores. Make sure to pick pharmaceutical-grade methylene blue if you’re taking it for health purposes.

            Also, look up the reviews and ratings of the specific supplement brand you are interested in buying.


            Methylene blue is a versatile compound with uses ranging from treating fish diseases to potentially boosting brain health in humans. Its antioxidant and anti-microbial benefits make it valuable, but remember to follow the right dosage and be mindful of possible drug interactions.


            1. How does methylene blue work, and what is its mechanism of action?
            Methylene blue helps blood carry oxygen, improves mitochondrial energy production, and reduces oxidative stress. It increases cellular oxygen consumption and acts as an antioxidant to support cellular repair.

            2. Is methylene blue safe, and what are its long-term side effects?
            Methylene blue is generally safe if taken within recommended doses. However, high doses over time can lead to neurological issues. Always consult a healthcare provider, especially if you’re on SSRIs or MAO inhibitors.

            3. Can methylene blue be combined with other therapies or treatments?
            Combining methylene blue with red light therapy may enhance brain health and cellular energy production. It’s also sometimes used alongside other treatments for cognitive enhancement and as a urinary antiseptic.

            4. How does eosin methylene blue (EMB) agar work, and what are the results used for?
            EMB agar differentiates between lactose-fermenting and non-lactose-fermenting bacteria based on the color changes in bacterial colonies. It’s commonly used in microbiology to identify bacterial species.

            5. What is the best methylene blue supplement, and where can I find it near me?
            Look for pharmaceutical-grade methylene blue from trusted suppliers, either online or in specialty supplement stores. Ensure it is pure and safe for human consumption.

            6. Why is methylene blue necessary, and what makes it unique?
            Methylene blue’s ability to treat medical conditions, stain cells for research, and help in fish care makes it versatile. Its antioxidant and mitochondrial support properties give it unique potential in both traditional medicine and cutting-edge therapies.