DIM 3X Review (2024) – Legit Estrogen-Reducing Supplement?

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DIM 3X is a dietary supplement developed by Leading Edge Health. Its principal compound, DIM, is created by the digestion of cruciferous vegetables, such as broccoli or Brussels sprouts, in the stomach³.

Hormone imbalance can affect anyone. Feelings of lethargy, disinterest in sex, or just generally feeling “off” aren’t normal. Neither is memory loss, inability to focus, or irritability. Often considered as typical signs of ageing, these symptoms can affect anyone, more commonly, people suffering from hormone imbalance or low testosterone (Low-T). Just because they’re common doesn’t mean you have to continue suffering!

Ingredients in Primegenix DIM 3X

1. Diindolylmethane (DIM): Studied for its potential health benefits, including hormone balance, antioxidant activity, and support for cellular function.
2. BioPerine: A patented extract from black pepper which enhances the absorption and bioavailability of nutrients in the body. Also, it aids in maximizing the effectiveness of DIM by improving its absorption into the bloodstream.
3. Astragin: Improves the absorption of Diindolylmethane (DIM)
4. Vitamin E: Known for its antioxidant properties, vitamin E plays a crucial role in supporting immune function and protecting cells from oxidative damage.

How does it work?

DIM is an aromatase inhibitor⁵. Aromatase is an enzyme that converts testosterone to estrogen. Slowing down the conversion of testosterone to estrogen can free up some of your testosterone, maintain better estrogen levels, and balance out your hormones.

DIM stimulates the production of a less potent, more beneficial form of estrogen known as 2-hydroxyestrone¹. Additionally, DIM has been shown to inhibit an enzyme called aromatase, which converts testosterone to estrogen ¹.

It also helps reduce the effects of a stronger form called 16 alpha-hydroxyestrone, which has been linked to weight gain and an increased risk of some cancers, including breast and uterine cancer^1,2.

Why Do Men Need DIM to Balance Estrogen?

DIM supports a ‘good’ healthy estrogen metabolism and reduces the less desirable or ‘bad’ estrogen metabolites, thereby increasing testosterone concentrations to healthy levels. Why is that important for men?

Low-T has been all over the media, so you probably know why you don’t want to have low testosterone levels, but just in case, here’s the shortlist:

• Low-T is associated with low libido and erectile dysfunction.
• Low-T can cause weight gain.
• Adequate T-levels support healthy muscle mass.
• Optimal testosterone levels give you more energy
• Testosterone boosts stamina.

Benefits of taking DIM 3X

1. Researchers have looked at the anti-inflammatory effects of DIM, mostly in animal studies. One study showed DIM helped turn off the inflammation response in mouse lung tissue, as well as duck liver and spleen tissue.
2. DIM is known to have anti-cancer properties. Lab studies not involving humans suggest DIM supplements may help prevent the growth and spread of breast cancer cells.
3. DIM protects against prostate problems. One condition that can lead to prostate cancer is called prostatic intraepithelial neoplasia (PIN). When you have it, cells grow in your prostate, promoting cancer. DIM supplements may help prevent PIN, which can reduce your chance of prostate enlargement and prostate cancer.
4. DIM helps with weight loss. Most studies of DIM affecting weight loss have involved animals. However, these studies suggest DIM supplements may cause fat breakdown and keep fat cells from forming. In humans, research does show that an estrogen imbalance can increase your risk of weight gain. More research is needed
5. Fights acne. DIM may fight acne⁴. DIM supplements are sometimes used to treat hormonal acne.
6. DIM helps reduce hot flashes. Hot flashes happen because of hormone imbalances, which is why some people take DIM to help treat them. There isn’t research to back DIM as a treatment.

Potential side effects and precautions

Due to a lack of research in humans, little is known about the long-term safety and side effects of DIM supplements.

Current human research doesn’t show DIM supplements to be toxic or have serious side effects. The most common side effects include:

• darkening of the urine,
• an increase in bowel movements,
• headache,
• gas.

 Less common side effects include:

•  nausea,
•  vomiting,
• diarrhoea,
•  skin rash.

DIM supplements interact with estrogen levels and may affect people with hormone-sensitive cancers or who are on hormone therapies. Such individuals should steer clear of DIM supplements unless under the supervision of a medical professional.

No matter your medical history, it’s important to consult your healthcare provider before taking these supplements.

DIM Supplements for Men Will Do It!

What if you don’t like cruciferous vegetables? Or what if you have to limit your servings of cruciferous vegetables because they can suppress thyroid production?

The thing is, even if you love your cabbage, broccoli, and Brussels sprouts, sometimes you need more than just a few servings of them a day. Sometimes you need a truckful. The best way to get that is through DIM supplements.

About the company:

PrimeGENIX is a line of premium fitness supplements designed for men over 40. Leading Edge Health, the company behind this product, claims to replenish the adult male body with natural supplements to enable it to continue all its activities even during the later years of life. It’s the same company behind Testostil, a testosterone-boosting supplement.

Website: Primegenix DIM 3X Official website

Dosage: According to the manufacturer, the recommended daily dosage is 100–200 mg.

Research:

Research suggests that DIM affects estrogen levels in your body1. As a result, DIM supplements have been gaining popularity as a potential treatment for a variety of hormone-related conditions, including acne, menopause symptoms, prostate issues, and certain forms of cancer.

1. University of California, Berkeley, California – 2006⁶

3,3′-Diindolylmethane Is a Novel Mitochondrial H+-ATP Synthase Inhibitor that Can Induce p21 Cip1/Waf1 Expression by Induction of Oxidative Stress in Human Breast Cancer Cells

Condition(s) Tested For: To establish the role of DIM in treatment of human breast cancer.

Outcome of the Study: Epidemiologic evidence suggests that a high dietary intake of Brassica vegetables, such as broccoli, cabbage, and Brussels sprouts, protects against tumorigenesis in multiple organs. 3,3′-Diindolylmethane, one of the active products derived from Brassica vegetables, is a promising antitumor agent.

2. The Feinstein Institute for Medical Research, Manhasset, New York – 2009⁷

Diindolylmethane Inhibits Cervical Dysplasia, Alters Estrogen Metabolism, and Enhances Immune Response in the K14-HPV16 Transgenic Mouse Model

Condition(s) Tested For: To establish whether DIM can inhibit cervical lesions, and alter estrogen metabolism.

Outcome of the Study: DIM decreases cell proliferation and papillae invasion and prevents the thickening of the cervical epithelium.

3. Technion – Israel Institute of Technology, Haifa, Israel – 2010⁸

The potential efficacy of 3,30-diindolylmethane in prevention of prostate cancer development

Condition(s) Tested For: Prostate cancer in men.

Outcome of the Study: DIM plays a role as an important antitumorigenic food derivative against prostate cancer.

4. Department of Microbiology and Immunology, New York Medical College, Valhalla, New York – 2011⁹

DIM Modulates Estrogen Metabolism in Patients with Thyroid Proliferative Disease: A Pilot Study

Condition(s) Tested For: Investigate the anti-estrogenic activity of DIM in thyroid proliferative disease

Outcome of the Study: DIM enhances estrogen metabolism in TPD patients and can potentially serve as an antiestrogenic dietary supplement to help reduce the risk of developing TPD. The fact that DIM is detected in thyroid tissue implies that it can manifest its antiestrogenic activity in situ to modulate TPD.

Conclusion:

DIM 3X is a natural supplement which has many beneficial effects in the body. Clinical studies have also shown that it prevents various forms of cancer.

Although human studies are limited. It may have side effects in some sperm characteristics.¹⁰

Exercise, healthy dietary habits, a good sleep and weight lifting can improve natural testosterone levels.

DIM 3X FAQ

• What does DIM do in the body?

Research suggests DIM reduces the estrogen that can cause harm in high amounts and increases the type of estrogen that helps prevent or treat cancer.

• How do I take it?

Supplementing with DIM 3X is simple. Just take 1 capsule daily, with meals. Just remember, DIM 3X is a daily formula, for best results, please take it every day.

• Does DIM increase testosterone?

It does not raise testosterone levels, but by balancing out estrogen, it helps support the activity of testosterone. 

• What Are the Side Effects of DIM Supplements?

Minimal side effects have been shown with DIM supplements for men. The most common side effects are:

1. Increased bowel movements
2. Darkening of urine
3. Headaches
4. Gas
5. Smelly urine

If you already know that you have hormone sensitivity or have had trouble with hormone therapies, DIM might not be appropriate for you.

• Can Primegenix DIM 3X be taken with other medications or supplements?

Potential interactions should be considered when taking Primegenix DIM 3X with medications or supplements. It is important to follow the recommended dosage guidelines and take safety precautions, especially if you have pre-existing medical conditions. Alternative options for DIM supplements are available in the market, and combination therapy with other natural remedies for hormonal balance may also be considered.

• Are there any specific dietary restrictions while taking Primegenix DIM 3X?

In terms of dietary restrictions, Primegenix DIM 3X does not have any specific requirements. However, it is always advisable to follow a balanced diet. The dosage instructions, benefits, long-term effects, and alternative supplements can be found in the product’s information leaflet.

• Why is DIM 3X so different from everything else available?

DIM 3X™ is the superior natural option for balancing your hormones for three reasons:

• First, is dosage. DIM 3X™ is clinically dosed with 200 mg of high-quality DIM. This dosage has been used successfully in human clinical studies.
  • Second, is absorption. Our dual-patented formula is equipped with AstraGin and BioPerine for enhanced nutritional absorption. This enhances the benefits drastically.
  • Third, extra hormone support. Our formula includes Vitamin E, which is shown to support healthy testosterone levels. And the fact is, research shows the majority of men over 40 lack proper levels of Vitamin E, which can severely mess with your hormones.

Disclaimer:

Please note that the writer of this article has not tried these products. All information presented is purely research-based and correct at the time of publication.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Please consult with a physician or other healthcare professional regarding any medical, health health-related issues for diagnosis and treatment.

References:

1. Thomson CA, Ho E, Strom MB. Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies. Nutr Rev. 2016 Jul;74(7):432-43. doi: 10.1093/nutrit/nuw010. Epub 2016 May 31. PMID: 27261275; PMCID: PMC5059820.
2. Rajoria S, Suriano R, Parmar PS, Wilson YL, Megwalu U, Moscatello A, Bradlow HL, Sepkovic DW, Geliebter J, Schantz SP, Tiwari RK. 3,3′-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. Thyroid. 2011 Mar;21(3):299-304. doi: 10.1089/thy.2010.0245. Epub 2011 Jan 22. PMID: 21254914; PMCID: PMC3048776.
3. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 2012 Jan 3;106(1):45-52. doi: 10.1038/bjc.2011.496. Epub 2011 Nov 10. PMID: 22075942; PMCID: PMC3251847.
4. Schultz TR. In search of ant ancestors. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14028-9. doi: 10.1073/pnas.011513798. PMID: 11106367; PMCID: PMC34089.
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059820/#ref-list-a.l.btitle
6. Gong Y, Sohn H, Xue L, Firestone GL, Bjeldanes LF. 3,3′-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. Cancer Res. 2006 May 1;66(9):4880-7. doi: 10.1158/0008-5472.CAN-05-4162. PMID: 16651444.
7. Sepkovic DW, Stein J, Carlisle AD, Ksieski HB, Auborn K, Bradlow HL. Diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the K14-HPV16 transgenic mouse model. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2957-64. doi: 10.1158/1055-9965.EPI-09-0698. Epub 2009 Oct 27. Erratum in: Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):628. PMID: 19861518; PMCID: PMC2783856.
8. Fares F, Azzam N, Appel B, Fares B, Stein A. The potential efficacy of 3,3′-diindolylmethane in prevention of prostate cancer development. Eur J Cancer Prev. 2010 May;19(3):199-203. doi: 10.1097/CEJ.0b013e328333fbce. PMID: 20010430.
9. NRajoria S, Suriano R, Parmar PS, Wilson YL, Megwalu U, Moscatello A, Bradlow HL, Sepkovic DW, Geliebter J, Schantz SP, Tiwari RK. 3,3′-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. Thyroid. 2011 Mar;21(3):299-304. doi: 10.1089/thy.2010.0245. Epub 2011 Jan 22. PMID: 21254914; PMCID: PMC3048776.
10. Aksu EH, Akman O, Ömür AD, Karakuş E, Can I, Kandemir FM, Dorman E, Uçar Ö. 3,3 diindolylmethane leads to apoptosis, decreases sperm quality, affects blood estradiol 17 β and testosterone, oestrogen (α and β) and androgen receptor levels in the reproductive system in male rats. Andrologia. 2016 Dec;48(10):1155-1165. doi: 10.1111/and.12554. Epub 2016 Feb 29. PMID: 26926141.